As young boys, Edward & Alphonse Elric dabbled in alchemy to try to resurrect their dead mother. As a result, Ed lost one arm and one leg, while Al lost his entire body and had his spirit sealed into a suit of armor. Now, they are searching for the fabled Philosopher's Stone to restore what they've lost.

Ed and Alphonse try to use their newfound skills to resurrect their dead mother, but by doing so they encounter something more terrifying than death.

Despite his powers, Edward must watch his back when a mysterious killer begins stalking state alchemists.

The raid on the Devil's Nest becomes a slaughter, leaving Ed and Al forever affected by the battle. Foreign travelers, Mei and Ling, arrive from the country of Xing, searching for the Philosopher's Stone and a secret even the Elric brothers never imagined.