Two turkeys from opposite sides of the tracks must put aside their differences and team up to travel back in time to change the course of history, and get turkey off the holiday menu for good.

One day, Horton the elephant hears a cry for help coming from a speck of dust. Even though he can't see anyone on the speck, he decides to help it. Good thing since as it turns out, the speck of dust is home to the Whos, who live in their city of Whoville. Horton agrees to help protect the Whos and their home. Unfortunately for Horton, this gives him nothing but torment from his neighbors. They refuse to believe that anything could survive on the...