In an attempt to open his daughter, Dr. Cara Harding, up to accepting unexplainable psychiatric theories, her father introduces her to Adam, a patient with multiple personalities who takes on some of the physical characteristics of his other personalities. Cara quickly discovers that Adam's other personalities are murder victims and the more she finds out about him and his past, the closer she and her loved ones are to becoming murder victims themselves....

A charismatic young Irish guitarist and a sheltered young cellist have a chance encounter one magical night above New York's Washington Square. They are soon torn apart, leaving in their wake an infant, August Rush, orphaned by circumstance. Now performing on the streets of New York City and cared for by a mysterious stranger, August uses his remarkable musical talent to seek the parents from whom he was separated at birth.