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Best friends Lennie and George find themselves unemployed in Depression-era California, unable to maintain a stable working pattern for long because of Lennie's infantile mental capacity. They get hired at the Tyler Ranch but soon their work is ripped apart by tragedy when Curly's beautiful but unhappy wife becomes the innocent victim of Lennie's compassion.

Tells the story about the strange relationship of two migrant workers who are able to realize their dreams of an easy life until one of them succumbs to his weakness for soft, helpless creatures and strangles the farmer's wife.