Five friends from college reunite when they rent a beach house in Miami for a wild bachelorette weekend that goes completely off the rails. Just when all hope is lost, they realize there's more to the story than they could've ever imagined.

Although he has been missing for several years and the entire town thinks her father has abandoned her family, Meg steadfastly believes the best and protects her younger brother, Charles Wallace, from the brunt of the rumors and taunting. It is he, however, who convinces her to join him, the school sports star Calvin, and three unusual women on an interplanetary voyage to rescue their father from a vast evil.